Getting to the Root Cause of Mast Cell Activation Syndrome
Sep 15, 2025
Mast cell activation syndrome (MCAS) is a complex condition that involves the immune response and affects multiple systems in the body. Some people suffer for years with unexplained symptoms before receiving answers.
At Market Place Naturopathic, an integrative medicine and naturopathic practice in Seattle, Washington, we believe healing begins with understanding the “why” behind your symptoms and gently restoring balance to your body.
That’s why we specialize in getting to the root cause of MCAS while developing a personalized treatment strategy that supports healing.
Here’s more information from our team regarding the “what” and “why” of MCAS, as well as the strategies we use to help you overcome this challenging condition.
Mast cells are crucial components of your immune system. They act like first responders, releasing chemicals such as histamine in response to potential threats.
In MCAS, these mast cells become overly reactive, releasing mediators too frequently or inappropriately. This can create a wide range of symptoms, including:
Because symptoms vary so widely from person to person and often come on suddenly without an identified trigger, MCAS is frequently overlooked or misdiagnosed.
At Market Place Naturopathic, we view MCAS not as the final word but as a signal from your body that something deeper is at play.
Common root causes of MCAS include:
Viral, bacterial, or fungal imbalances can keep your immune system in a state of overdrive.
Mold exposure, chemical sensitivities, or heavy metals can contribute to mast cell dysregulation.
Leaky gut, dysbiosis, food intolerances, and other conditions affecting gut health often play a central role in MCAS.
Emotional and physical stress can activate mast cells, thereby amplifying symptoms.
Key nutrients, such as magnesium, vitamin C, and quercetin, help stabilize mast cell function. A deficiency could disrupt this process.
When we address these underlying factors, many of our patients experience profound improvement in both their symptoms and their overall quality of life.
Every patient with MCAS is unique. That’s why we take an individualized approach, combining advanced testing with natural therapies to support your body’s healing capacity.
This personalized approach may include:
Rather than chasing symptoms, our goal is to create a healing plan that supports the whole person: body, mind, and spirit.
Living with MCAS can seem overwhelming, but you aren’t alone. There are solutions. With support, it’s possible to uncover the root causes, calm the immune system, and restore balance.
If you suspect you may be dealing with MCAS, or if you’ve struggled with mysterious, multi-system symptoms, we invite you to connect with us. Take the next step toward understanding your body and reclaiming your health.
Contact us at Market Place Naturopathic today, and submit a new patient form to request a complimentary 15-minute phone consultation with one of our naturopathic doctors. This helps us determine if our integrative approach is right for you.